Abstract: Pigment epithelium-derived factor (PEDF) is an endogenous glycoprotein and a member of the noninhibitory serine protease inhibitor superfamily. It has biological functions such as neuronutrition, anti-neovascularization, anti-inflammatory and antioxidant. Numerous studies have shown that PEDF plays a protective role in the pathogenesis of various ocular surface diseases (such as keratitis, corneal neovascular disorders, dry eye, etc.) by promoting corneal nerve regeneration, inhibiting corneal neovascularization, reduce inflammatory response.